A prospective evaluation of early detection biomarkers for ovarian cancer in the European EPIC cohort
Identifieur interne : 002443 ( Main/Exploration ); précédent : 002442; suivant : 002444A prospective evaluation of early detection biomarkers for ovarian cancer in the European EPIC cohort
Auteurs : Kathryn L. Terry [États-Unis] ; Helena Schock [Allemagne] ; Renée T. Fortner [Allemagne] ; Anika Hüsing [Allemagne] ; Raina N. Fichorova [États-Unis] ; Hidemi S. Yamamoto [États-Unis] ; Allison F. Vitonis [États-Unis] ; Theron Johnson [Allemagne] ; Kim Overvad [Danemark] ; Anne Tj Nneland [Danemark] ; Marie-Christine Boutron-Ruault [France] ; Sylvie Mesrine [France] ; Gianluca Severi [France, Italie, Australie] ; Laure Dossus ; Sabina Rinaldi ; Heiner Boeing [Allemagne] ; Vassiliki Benetou [Grèce] ; Pagona Lagiou [Grèce] ; Antonia Trichopoulou [Grèce] ; Vittorio Krogh [Italie] ; Elisabetta Kuhn [Italie] ; Salvatore Panico [Italie] ; H. Bas Bueno-De-Mesquita [Pays-Bas] ; N. Charlotte Onland-Moret [Pays-Bas] ; Petra H. Peeters [Pays-Bas] ; Inger Torhild Gram [Norvège] ; Elisabete Weiderpass [Norvège, Suède, Finlande] ; Eric J. Duell [Espagne] ; Maria-Jose Sanchez [Espagne] ; Eva Ardanaz [Espagne] ; Nerea Etxezarreta [Espagne] ; Carmen Navarro [Espagne] ; Annika Idahl [Suède] ; Eva Lundin [Suède] ; Karin Jirström [Suède] ; Jonas Manjer [Suède] ; Nicholas J. Wareham [Royaume-Uni] ; Kay-Tee Khaw [Royaume-Uni] ; Karl Smith Byrne [Royaume-Uni] ; Ruth C. Travis [Royaume-Uni] ; Marc J. Gunter [Royaume-Uni] ; Melissa A. Merritt [Royaume-Uni] ; Elio Riboli [Royaume-Uni] ; Daniel W. Cramer [États-Unis] ; Rudolf Kaaks [États-Unis]Source :
- Clinical cancer research : an official journal of the American Association for Cancer Research [ 1078-0432 ] ; 2016.
Abstract
About 60% of ovarian cancers are diagnosed at late stage, when 5-year survival is less than 30% in contrast to 90% for local disease. This has prompted search for early detection biomarkers. For initial testing, specimens taken months or years before ovarian cancer diagnosis are the best source of information to evaluate early detection biomarkers. Here we evaluate the most promising ovarian cancer screening biomarkers in prospectively collected samples from the European Prospective Investigation into Cancer and Nutrition study.
We measured CA125, HE4, CA72.4 and CA15.3 in 810 invasive epithelial ovarian cancer cases and 1,939 controls. We calculated the sensitivity at 95% and 98% specificity as well as Area under the Receiver Operator Curve (C-statistic) for each marker individually and in combination. Additionally, we evaluated marker performance by stage at diagnosis and time between blood draw and diagnosis.
We observed the best discrimination between cases and controls within six months of diagnosis for CA125 (C-statistic=0.92), then HE4 (0.84), CA72.4 (0.77), and CA15.3 (0.73). Marker performance declined with longer time between blood draw and diagnosis and for earlier staged disease. However, assessment of discriminatory ability at early stage was limited by small numbers. Combinations of markers performed modestly, but significantly better than any single marker.
CA125 remains the single best marker for the early detection of invasive epithelial ovarian cancer, but can be slightly improved by combining with other markers. Identifying novel markers for ovarian cancer will require studies including larger numbers of early stage cases.
Url:
DOI: 10.1158/1078-0432.CCR-16-0316
PubMed: 27060155
PubMed Central: 5026545
Affiliations:
- Allemagne, Australie, Danemark, Espagne, Finlande, France, Grèce, Italie, Norvège, Pays-Bas, Royaume-Uni, Suède, États-Unis
- Angleterre, Angleterre de l'Est, Bade-Wurtemberg, Catalogne, Communauté de Madrid, District de Karlsruhe, Grand Londres, Hovedstaden, Lombardie, Massachusetts, Oxfordshire, Piémont, Svealand, Utrecht (province), Île-de-France, Østlandet
- Barcelone, Cambridge, Copenhague, Heidelberg, Londres, Madrid, Milan, Orsay, Oslo, Oxford, Stockholm, Turin, Utrecht
- Université Paris-Sud, Université d'Oxford, Université de Cambridge
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and Metabolism section</wicri:noCountry></affiliation></author><author><name sortKey="Boeing, Heiner" sort="Boeing, Heiner" uniqKey="Boeing H" first="Heiner" last="Boeing">Heiner Boeing</name><affiliation wicri:level="1"><nlm:aff id="A12"> Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Nuthetal, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Nuthetal</wicri:regionArea><wicri:noRegion>Nuthetal</wicri:noRegion><wicri:noRegion>Nuthetal</wicri:noRegion><wicri:noRegion>Nuthetal</wicri:noRegion></affiliation></author><author><name sortKey="Benetou, Vassiliki" sort="Benetou, Vassiliki" uniqKey="Benetou V" first="Vassiliki" last="Benetou">Vassiliki Benetou</name><affiliation wicri:level="1"><nlm:aff id="A13"> Helenic Health Foundation Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Helenic Health Foundation Athens</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A14"> WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School</wicri:regionArea><wicri:noRegion>University of Athens Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Lagiou, Pagona" sort="Lagiou, Pagona" uniqKey="Lagiou P" first="Pagona" last="Lagiou">Pagona Lagiou</name><affiliation wicri:level="1"><nlm:aff id="A13"> Helenic Health Foundation Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Helenic Health Foundation Athens</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A14"> WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School</wicri:regionArea><wicri:noRegion>University of Athens Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Trichopoulou, Antonia" sort="Trichopoulou, Antonia" uniqKey="Trichopoulou A" first="Antonia" last="Trichopoulou">Antonia Trichopoulou</name><affiliation wicri:level="1"><nlm:aff id="A13"> Helenic Health Foundation Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Helenic Health Foundation Athens</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A14"> WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School</wicri:regionArea><wicri:noRegion>University of Athens Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Krogh, Vittorio" sort="Krogh, Vittorio" uniqKey="Krogh V" first="Vittorio" last="Krogh">Vittorio Krogh</name><affiliation wicri:level="3"><nlm:aff id="A15"> Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Kuhn, Elisabetta" sort="Kuhn, Elisabetta" uniqKey="Kuhn E" first="Elisabetta" last="Kuhn">Elisabetta Kuhn</name><affiliation wicri:level="1"><nlm:aff id="A16"> Department of Morphology, Surgery and Experimental Medicine and Laboratorio per le Tecnologie delle Terapie Avanzate (LTTA) Centre, University of Ferrara, Ferrara, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Department of Morphology, Surgery and Experimental Medicine and Laboratorio per le Tecnologie delle Terapie Avanzate (LTTA) Centre, University of Ferrara, Ferrara</wicri:regionArea><wicri:noRegion>Ferrara</wicri:noRegion></affiliation></author><author><name sortKey="Panico, Salvatore" sort="Panico, Salvatore" uniqKey="Panico S" first="Salvatore" last="Panico">Salvatore Panico</name><affiliation wicri:level="1"><nlm:aff id="A17"> Dipartimento di Medicina Clinical e Chirurgia, Federico II University, Naples, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Dipartimento di Medicina Clinical e Chirurgia, Federico II University, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Bueno De Mesquita, H Bas" sort="Bueno De Mesquita, H Bas" uniqKey="Bueno De Mesquita H" first="H. Bas" last="Bueno-De-Mesquita">H. Bas Bueno-De-Mesquita</name><affiliation wicri:level="1"><nlm:aff id="A18"> National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea> National Institute for Public Health and the Environment (RIVM), Bilthoven</wicri:regionArea><wicri:noRegion>Bilthoven</wicri:noRegion></affiliation></author><author><name sortKey="Onland Moret, N Charlotte" sort="Onland Moret, N Charlotte" uniqKey="Onland Moret N" first="N. Charlotte" last="Onland-Moret">N. Charlotte Onland-Moret</name><affiliation wicri:level="3"><nlm:aff id="A19"> Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea> Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H." last="Peeters">Petra H. Peeters</name><affiliation wicri:level="3"><nlm:aff id="A19"> Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea> Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Gram, Inger Torhild" sort="Gram, Inger Torhild" uniqKey="Gram I" first="Inger Torhild" last="Gram">Inger Torhild Gram</name><affiliation wicri:level="1"><nlm:aff id="A20"> Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea> Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø</wicri:regionArea><wicri:noRegion>Tromsø</wicri:noRegion></affiliation></author><author><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name><affiliation wicri:level="1"><nlm:aff id="A20"> Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea> Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø</wicri:regionArea><wicri:noRegion>Tromsø</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="A21"> Department of Research, Cancer Registry of Norway, Institute of Population-Based Case Research, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea> Department of Research, Cancer Registry of Norway, Institute of Population-Based Case Research, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A22"> Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea> Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A23"> Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea> Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Duell, Eric J" sort="Duell, Eric J" uniqKey="Duell E" first="Eric J." last="Duell">Eric J. Duell</name><affiliation wicri:level="3"><nlm:aff id="A24"> Unit of Nutrition and Cancer Cancer Epidemiology Research Program, Bellvitge Biomedical Research Institute, Catalan Institute of Oncology, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Unit of Nutrition and Cancer Cancer Epidemiology Research Program, Bellvitge Biomedical Research Institute, Catalan Institute of Oncology, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Sanchez, Maria Jose" sort="Sanchez, Maria Jose" uniqKey="Sanchez M" first="Maria-Jose" last="Sanchez">Maria-Jose Sanchez</name><affiliation wicri:level="1"><nlm:aff id="A25"> Escuela Andaluza de Salud Publica, Instituto de Investigación Bionsanitaria ibs. Granada, Hospitales Universitarios de Granada, Granada, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Escuela Andaluza de Salud Publica, Instituto de Investigación Bionsanitaria ibs. Granada, Hospitales Universitarios de Granada, Granada</wicri:regionArea><wicri:noRegion>Granada</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="A26"> Centro de Investigación Biomédica En Red (CIBER) , Section Epidemiology and Public Health (CIBERESP), Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Centro de Investigación Biomédica En Red (CIBER) , Section Epidemiology and Public Health (CIBERESP), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Ardanaz, Eva" sort="Ardanaz, Eva" uniqKey="Ardanaz E" first="Eva" last="Ardanaz">Eva Ardanaz</name><affiliation wicri:level="3"><nlm:aff id="A26"> Centro de Investigación Biomédica En Red (CIBER) , Section Epidemiology and Public Health (CIBERESP), Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Centro de Investigación Biomédica En Red (CIBER) , Section Epidemiology and Public Health (CIBERESP), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A27"> Navarra Public Health Institute, Pamplona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Navarra Public Health Institute, Pamplona</wicri:regionArea><wicri:noRegion>Pamplona</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A28"> IdiSNA, Navarra Institute for Health Research, Pamplona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> IdiSNA, Navarra Institute for Health Research, Pamplona</wicri:regionArea><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Etxezarreta, Nerea" sort="Etxezarreta, Nerea" uniqKey="Etxezarreta N" first="Nerea" last="Etxezarreta">Nerea Etxezarreta</name><affiliation wicri:level="3"><nlm:aff id="A26"> Centro de Investigación Biomédica En Red (CIBER) , Section Epidemiology and Public Health (CIBERESP), Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Centro de Investigación Biomédica En Red (CIBER) , Section Epidemiology and Public Health (CIBERESP), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A29"> Public Health Division of Gipuzkoa, Regional Government of the Basque Country, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Public Health Division of Gipuzkoa, Regional Government of the Basque Country</wicri:regionArea><wicri:noRegion>Regional Government of the Basque Country</wicri:noRegion></affiliation></author><author><name sortKey="Navarro, Carmen" sort="Navarro, Carmen" uniqKey="Navarro C" first="Carmen" last="Navarro">Carmen Navarro</name><affiliation wicri:level="3"><nlm:aff id="A26"> Centro de Investigación Biomédica En Red (CIBER) , Section Epidemiology and Public Health (CIBERESP), Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Centro de Investigación Biomédica En Red (CIBER) , Section Epidemiology and Public Health (CIBERESP), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A30"> Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia</wicri:regionArea><wicri:noRegion>Murcia</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A31"> Department of Health and Social Sciences, Universidad de Murcia, Murcia, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Department of Health and Social Sciences, Universidad de Murcia, Murcia</wicri:regionArea><wicri:noRegion>Murcia</wicri:noRegion></affiliation></author><author><name sortKey="Idahl, Annika" sort="Idahl, Annika" uniqKey="Idahl A" first="Annika" last="Idahl">Annika Idahl</name><affiliation wicri:level="1"><nlm:aff id="A32"> Department of Clinical Sciences, Obstetrics and Gynecology Umeå, University of Umeå, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea> Department of Clinical Sciences, Obstetrics and Gynecology Umeå, University of Umeå</wicri:regionArea><wicri:noRegion>University of Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Lundin, Eva" sort="Lundin, Eva" uniqKey="Lundin E" first="Eva" last="Lundin">Eva Lundin</name><affiliation wicri:level="1"><nlm:aff id="A33"> Department of Medical Biosciences, Pathology Umeå, University of Umeå, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea> Department of Medical Biosciences, Pathology Umeå, University of Umeå</wicri:regionArea><wicri:noRegion>University of Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Jirstrom, Karin" sort="Jirstrom, Karin" uniqKey="Jirstrom K" first="Karin" last="Jirström">Karin Jirström</name><affiliation wicri:level="1"><nlm:aff id="A34"> Department of Clinical Sciences Lund, Oncology and Pathology, Lund University, Lund, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea> Department of Clinical Sciences Lund, Oncology and Pathology, Lund University, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A35"> Department of Surgery, Skåne University Hospital, Lund University, Malmö, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea> Department of Surgery, Skåne University Hospital, Lund University, Malmö</wicri:regionArea><wicri:noRegion>Malmö</wicri:noRegion></affiliation></author><author><name sortKey="Manjer, Jonas" sort="Manjer, Jonas" uniqKey="Manjer J" first="Jonas" last="Manjer">Jonas Manjer</name><affiliation wicri:level="1"><nlm:aff id="A34"> Department of Clinical Sciences Lund, Oncology and Pathology, Lund University, Lund, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea> Department of Clinical Sciences Lund, Oncology and Pathology, Lund University, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A35"> Department of Surgery, Skåne University Hospital, Lund University, Malmö, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea> Department of Surgery, Skåne University Hospital, Lund University, Malmö</wicri:regionArea><wicri:noRegion>Malmö</wicri:noRegion></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J." last="Wareham">Nicholas J. Wareham</name><affiliation wicri:level="4"><nlm:aff id="A36"> Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation wicri:level="1"><nlm:aff id="A37"> University of Cambridge School of Clinical Medicine, Clinical Gerontology, Cambridge, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> University of Cambridge School of Clinical Medicine, Clinical Gerontology, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Byrne, Karl Smith" sort="Byrne, Karl Smith" uniqKey="Byrne K" first="Karl Smith" last="Byrne">Karl Smith Byrne</name><affiliation wicri:level="4"><nlm:aff id="A38"> Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name><affiliation wicri:level="4"><nlm:aff id="A38"> Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Gunter, Marc J" sort="Gunter, Marc J" uniqKey="Gunter M" first="Marc J." last="Gunter">Marc J. Gunter</name><affiliation wicri:level="3"><nlm:aff id="A39"> Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Merritt, Melissa A" sort="Merritt, Melissa A" uniqKey="Merritt M" first="Melissa A." last="Merritt">Melissa A. Merritt</name><affiliation wicri:level="3"><nlm:aff id="A39"> Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name><affiliation wicri:level="3"><nlm:aff id="A39"> Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Cramer, Daniel W" sort="Cramer, Daniel W" uniqKey="Cramer D" first="Daniel W." last="Cramer">Daniel W. Cramer</name><affiliation wicri:level="2"><nlm:aff id="A1"> Ob/Gyn Epidemiology Center, Brigham and Women's Hospital, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Ob/Gyn Epidemiology Center, Brigham and Women's Hospital, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name><affiliation wicri:level="2"><nlm:aff id="A2"> Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27060155</idno><idno type="pmc">5026545</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026545</idno><idno type="RBID">PMC:5026545</idno><idno type="doi">10.1158/1078-0432.CCR-16-0316</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">002179</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002179</idno><idno type="wicri:Area/Pmc/Curation">002030</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002030</idno><idno type="wicri:Area/Pmc/Checkpoint">000B60</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000B60</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">001997</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001997</idno><idno type="wicri:Area/PubMed/Curation">001973</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001973</idno><idno type="wicri:Area/PubMed/Checkpoint">001973</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001973</idno><idno type="wicri:Area/Ncbi/Merge">003385</idno><idno type="wicri:Area/Ncbi/Curation">003385</idno><idno type="wicri:Area/Ncbi/Checkpoint">003385</idno><idno type="wicri:doubleKey">1078-0432:2016:Terry K:a:prospective:evaluation</idno><idno type="wicri:Area/Main/Merge">002442</idno><idno type="wicri:Area/Main/Curation">002443</idno><idno type="wicri:Area/Main/Exploration">002443</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A prospective evaluation of early detection biomarkers for ovarian cancer in the European EPIC cohort</title><author><name sortKey="Terry, Kathryn L" sort="Terry, Kathryn L" uniqKey="Terry K" first="Kathryn L." last="Terry">Kathryn L. Terry</name><affiliation wicri:level="2"><nlm:aff id="A1"> Ob/Gyn Epidemiology Center, Brigham and Women's Hospital, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Ob/Gyn Epidemiology Center, Brigham and Women's Hospital, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A2"> Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Schock, Helena" sort="Schock, Helena" uniqKey="Schock H" first="Helena" last="Schock">Helena Schock</name><affiliation wicri:level="3"><nlm:aff id="A3"> Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Fortner, Renee T" sort="Fortner, Renee T" uniqKey="Fortner R" first="Renée T." last="Fortner">Renée T. Fortner</name><affiliation wicri:level="3"><nlm:aff id="A3"> Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Husing, Anika" sort="Husing, Anika" uniqKey="Husing A" first="Anika" last="Hüsing">Anika Hüsing</name><affiliation wicri:level="3"><nlm:aff id="A3"> Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Fichorova, Raina N" sort="Fichorova, Raina N" uniqKey="Fichorova R" first="Raina N." last="Fichorova">Raina N. Fichorova</name><affiliation wicri:level="2"><nlm:aff id="A2"> Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A4"> Genital Tract Biology Laboratory, Brigham and Women's Hospital, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Genital Tract Biology Laboratory, Brigham and Women's Hospital, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Yamamoto, Hidemi S" sort="Yamamoto, Hidemi S" uniqKey="Yamamoto H" first="Hidemi S." last="Yamamoto">Hidemi S. Yamamoto</name><affiliation wicri:level="2"><nlm:aff id="A2"> Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A4"> Genital Tract Biology Laboratory, Brigham and Women's Hospital, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Genital Tract Biology Laboratory, Brigham and Women's Hospital, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Vitonis, Allison F" sort="Vitonis, Allison F" uniqKey="Vitonis A" first="Allison F." last="Vitonis">Allison F. Vitonis</name><affiliation wicri:level="2"><nlm:aff id="A1"> Ob/Gyn Epidemiology Center, Brigham and Women's Hospital, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Ob/Gyn Epidemiology Center, Brigham and Women's Hospital, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Johnson, Theron" sort="Johnson, Theron" uniqKey="Johnson T" first="Theron" last="Johnson">Theron Johnson</name><affiliation wicri:level="3"><nlm:aff id="A3"> Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Overvad, Kim" sort="Overvad, Kim" uniqKey="Overvad K" first="Kim" last="Overvad">Kim Overvad</name><affiliation wicri:level="1"><nlm:aff id="A5"> Department of Epidemiology, Aarhus University, Aarhus, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea> Department of Epidemiology, Aarhus University, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Tj Nneland, Anne" sort="Tj Nneland, Anne" uniqKey="Tj Nneland A" first="Anne" last="Tj Nneland">Anne Tj Nneland</name><affiliation wicri:level="3"><nlm:aff id="A6"> Danish Cancer Society Research Center, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea> Danish Cancer Society Research Center, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Boutron Ruault, Marie Christine" sort="Boutron Ruault, Marie Christine" uniqKey="Boutron Ruault M" first="Marie-Christine" last="Boutron-Ruault">Marie-Christine Boutron-Ruault</name><affiliation wicri:level="4"><nlm:aff id="A7"> Université Paris-Sud, Centre de recherche en Épidémiologie et Santé des Populations (CESP), Institut Nationale de Santë et de Recherche Médicale (INSERM), Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Université Paris-Sud, Centre de recherche en Épidémiologie et Santé des Populations (CESP), Institut Nationale de Santë et de Recherche Médicale (INSERM), Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><orgName type="university">Université Paris-Sud</orgName><placeName><settlement type="city">Orsay</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A8"> Gustave Roussy, F-94805, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Gustave Roussy, F-94805, Villejuif</wicri:regionArea><wicri:noRegion>94805, Villejuif</wicri:noRegion><wicri:noRegion>94805, Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Mesrine, Sylvie" sort="Mesrine, Sylvie" uniqKey="Mesrine S" first="Sylvie" last="Mesrine">Sylvie Mesrine</name><affiliation wicri:level="4"><nlm:aff id="A7"> Université Paris-Sud, Centre de recherche en Épidémiologie et Santé des Populations (CESP), Institut Nationale de Santë et de Recherche Médicale (INSERM), Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Université Paris-Sud, Centre de recherche en Épidémiologie et Santé des Populations (CESP), Institut Nationale de Santë et de Recherche Médicale (INSERM), Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><orgName type="university">Université Paris-Sud</orgName><placeName><settlement type="city">Orsay</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A8"> Gustave Roussy, F-94805, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Gustave Roussy, F-94805, Villejuif</wicri:regionArea><wicri:noRegion>94805, Villejuif</wicri:noRegion><wicri:noRegion>94805, Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation wicri:level="4"><nlm:aff id="A7"> Université Paris-Sud, Centre de recherche en Épidémiologie et Santé des Populations (CESP), Institut Nationale de Santë et de Recherche Médicale (INSERM), Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Université Paris-Sud, Centre de recherche en Épidémiologie et Santé des Populations (CESP), Institut Nationale de Santë et de Recherche Médicale (INSERM), Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><orgName type="university">Université Paris-Sud</orgName><placeName><settlement type="city">Orsay</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A8"> Gustave Roussy, F-94805, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Gustave Roussy, F-94805, Villejuif</wicri:regionArea><wicri:noRegion>94805, Villejuif</wicri:noRegion><wicri:noRegion>94805, Villejuif</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="A9"> Human Genetics Foundation (HuGeF), Torino, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Human Genetics Foundation (HuGeF), Torino</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A10"> Cancer Council Victoria and University of Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> Cancer Council Victoria and University of Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Dossus, Laure" sort="Dossus, Laure" uniqKey="Dossus L" first="Laure" last="Dossus">Laure Dossus</name><affiliation><nlm:aff id="A11"> International Agency for Research on Cancer, Lyon, France, Nutrition and Metabolism section</nlm:aff><wicri:noCountry code="subfield">Nutrition and Metabolism section</wicri:noCountry></affiliation></author><author><name sortKey="Rinaldi, Sabina" sort="Rinaldi, Sabina" uniqKey="Rinaldi S" first="Sabina" last="Rinaldi">Sabina Rinaldi</name><affiliation><nlm:aff id="A11"> International Agency for Research on Cancer, Lyon, France, Nutrition and Metabolism section</nlm:aff><wicri:noCountry code="subfield">Nutrition and Metabolism section</wicri:noCountry></affiliation></author><author><name sortKey="Boeing, Heiner" sort="Boeing, Heiner" uniqKey="Boeing H" first="Heiner" last="Boeing">Heiner Boeing</name><affiliation wicri:level="1"><nlm:aff id="A12"> Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Nuthetal, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Nuthetal</wicri:regionArea><wicri:noRegion>Nuthetal</wicri:noRegion><wicri:noRegion>Nuthetal</wicri:noRegion><wicri:noRegion>Nuthetal</wicri:noRegion></affiliation></author><author><name sortKey="Benetou, Vassiliki" sort="Benetou, Vassiliki" uniqKey="Benetou V" first="Vassiliki" last="Benetou">Vassiliki Benetou</name><affiliation wicri:level="1"><nlm:aff id="A13"> Helenic Health Foundation Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Helenic Health Foundation Athens</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A14"> WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School</wicri:regionArea><wicri:noRegion>University of Athens Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Lagiou, Pagona" sort="Lagiou, Pagona" uniqKey="Lagiou P" first="Pagona" last="Lagiou">Pagona Lagiou</name><affiliation wicri:level="1"><nlm:aff id="A13"> Helenic Health Foundation Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Helenic Health Foundation Athens</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A14"> WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School</wicri:regionArea><wicri:noRegion>University of Athens Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Trichopoulou, Antonia" sort="Trichopoulou, Antonia" uniqKey="Trichopoulou A" first="Antonia" last="Trichopoulou">Antonia Trichopoulou</name><affiliation wicri:level="1"><nlm:aff id="A13"> Helenic Health Foundation Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Helenic Health Foundation Athens</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A14"> WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School</wicri:regionArea><wicri:noRegion>University of Athens Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Krogh, Vittorio" sort="Krogh, Vittorio" uniqKey="Krogh V" first="Vittorio" last="Krogh">Vittorio Krogh</name><affiliation wicri:level="3"><nlm:aff id="A15"> Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Kuhn, Elisabetta" sort="Kuhn, Elisabetta" uniqKey="Kuhn E" first="Elisabetta" last="Kuhn">Elisabetta Kuhn</name><affiliation wicri:level="1"><nlm:aff id="A16"> Department of Morphology, Surgery and Experimental Medicine and Laboratorio per le Tecnologie delle Terapie Avanzate (LTTA) Centre, University of Ferrara, Ferrara, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Department of Morphology, Surgery and Experimental Medicine and Laboratorio per le Tecnologie delle Terapie Avanzate (LTTA) Centre, University of Ferrara, Ferrara</wicri:regionArea><wicri:noRegion>Ferrara</wicri:noRegion></affiliation></author><author><name sortKey="Panico, Salvatore" sort="Panico, Salvatore" uniqKey="Panico S" first="Salvatore" last="Panico">Salvatore Panico</name><affiliation wicri:level="1"><nlm:aff id="A17"> Dipartimento di Medicina Clinical e Chirurgia, Federico II University, Naples, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Dipartimento di Medicina Clinical e Chirurgia, Federico II University, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Bueno De Mesquita, H Bas" sort="Bueno De Mesquita, H Bas" uniqKey="Bueno De Mesquita H" first="H. Bas" last="Bueno-De-Mesquita">H. Bas Bueno-De-Mesquita</name><affiliation wicri:level="1"><nlm:aff id="A18"> National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea> National Institute for Public Health and the Environment (RIVM), Bilthoven</wicri:regionArea><wicri:noRegion>Bilthoven</wicri:noRegion></affiliation></author><author><name sortKey="Onland Moret, N Charlotte" sort="Onland Moret, N Charlotte" uniqKey="Onland Moret N" first="N. Charlotte" last="Onland-Moret">N. Charlotte Onland-Moret</name><affiliation wicri:level="3"><nlm:aff id="A19"> Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea> Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H." last="Peeters">Petra H. Peeters</name><affiliation wicri:level="3"><nlm:aff id="A19"> Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea> Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Gram, Inger Torhild" sort="Gram, Inger Torhild" uniqKey="Gram I" first="Inger Torhild" last="Gram">Inger Torhild Gram</name><affiliation wicri:level="1"><nlm:aff id="A20"> Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea> Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø</wicri:regionArea><wicri:noRegion>Tromsø</wicri:noRegion></affiliation></author><author><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name><affiliation wicri:level="1"><nlm:aff id="A20"> Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea> Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø</wicri:regionArea><wicri:noRegion>Tromsø</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="A21"> Department of Research, Cancer Registry of Norway, Institute of Population-Based Case Research, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea> Department of Research, Cancer Registry of Norway, Institute of Population-Based Case Research, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A22"> Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea> Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A23"> Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea> Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Duell, Eric J" sort="Duell, Eric J" uniqKey="Duell E" first="Eric J." last="Duell">Eric J. Duell</name><affiliation wicri:level="3"><nlm:aff id="A24"> Unit of Nutrition and Cancer Cancer Epidemiology Research Program, Bellvitge Biomedical Research Institute, Catalan Institute of Oncology, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Unit of Nutrition and Cancer Cancer Epidemiology Research Program, Bellvitge Biomedical Research Institute, Catalan Institute of Oncology, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Sanchez, Maria Jose" sort="Sanchez, Maria Jose" uniqKey="Sanchez M" first="Maria-Jose" last="Sanchez">Maria-Jose Sanchez</name><affiliation wicri:level="1"><nlm:aff id="A25"> Escuela Andaluza de Salud Publica, Instituto de Investigación Bionsanitaria ibs. Granada, Hospitales Universitarios de Granada, Granada, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Escuela Andaluza de Salud Publica, Instituto de Investigación Bionsanitaria ibs. Granada, Hospitales Universitarios de Granada, Granada</wicri:regionArea><wicri:noRegion>Granada</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="A26"> Centro de Investigación Biomédica En Red (CIBER) , Section Epidemiology and Public Health (CIBERESP), Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Centro de Investigación Biomédica En Red (CIBER) , Section Epidemiology and Public Health (CIBERESP), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Ardanaz, Eva" sort="Ardanaz, Eva" uniqKey="Ardanaz E" first="Eva" last="Ardanaz">Eva Ardanaz</name><affiliation wicri:level="3"><nlm:aff id="A26"> Centro de Investigación Biomédica En Red (CIBER) , Section Epidemiology and Public Health (CIBERESP), Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Centro de Investigación Biomédica En Red (CIBER) , Section Epidemiology and Public Health (CIBERESP), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A27"> Navarra Public Health Institute, Pamplona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Navarra Public Health Institute, Pamplona</wicri:regionArea><wicri:noRegion>Pamplona</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A28"> IdiSNA, Navarra Institute for Health Research, Pamplona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> IdiSNA, Navarra Institute for Health Research, Pamplona</wicri:regionArea><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Etxezarreta, Nerea" sort="Etxezarreta, Nerea" uniqKey="Etxezarreta N" first="Nerea" last="Etxezarreta">Nerea Etxezarreta</name><affiliation wicri:level="3"><nlm:aff id="A26"> Centro de Investigación Biomédica En Red (CIBER) , Section Epidemiology and Public Health (CIBERESP), Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Centro de Investigación Biomédica En Red (CIBER) , Section Epidemiology and Public Health (CIBERESP), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A29"> Public Health Division of Gipuzkoa, Regional Government of the Basque Country, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Public Health Division of Gipuzkoa, Regional Government of the Basque Country</wicri:regionArea><wicri:noRegion>Regional Government of the Basque Country</wicri:noRegion></affiliation></author><author><name sortKey="Navarro, Carmen" sort="Navarro, Carmen" uniqKey="Navarro C" first="Carmen" last="Navarro">Carmen Navarro</name><affiliation wicri:level="3"><nlm:aff id="A26"> Centro de Investigación Biomédica En Red (CIBER) , Section Epidemiology and Public Health (CIBERESP), Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Centro de Investigación Biomédica En Red (CIBER) , Section Epidemiology and Public Health (CIBERESP), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A30"> Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia</wicri:regionArea><wicri:noRegion>Murcia</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A31"> Department of Health and Social Sciences, Universidad de Murcia, Murcia, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Department of Health and Social Sciences, Universidad de Murcia, Murcia</wicri:regionArea><wicri:noRegion>Murcia</wicri:noRegion></affiliation></author><author><name sortKey="Idahl, Annika" sort="Idahl, Annika" uniqKey="Idahl A" first="Annika" last="Idahl">Annika Idahl</name><affiliation wicri:level="1"><nlm:aff id="A32"> Department of Clinical Sciences, Obstetrics and Gynecology Umeå, University of Umeå, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea> Department of Clinical Sciences, Obstetrics and Gynecology Umeå, University of Umeå</wicri:regionArea><wicri:noRegion>University of Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Lundin, Eva" sort="Lundin, Eva" uniqKey="Lundin E" first="Eva" last="Lundin">Eva Lundin</name><affiliation wicri:level="1"><nlm:aff id="A33"> Department of Medical Biosciences, Pathology Umeå, University of Umeå, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea> Department of Medical Biosciences, Pathology Umeå, University of Umeå</wicri:regionArea><wicri:noRegion>University of Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Jirstrom, Karin" sort="Jirstrom, Karin" uniqKey="Jirstrom K" first="Karin" last="Jirström">Karin Jirström</name><affiliation wicri:level="1"><nlm:aff id="A34"> Department of Clinical Sciences Lund, Oncology and Pathology, Lund University, Lund, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea> Department of Clinical Sciences Lund, Oncology and Pathology, Lund University, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A35"> Department of Surgery, Skåne University Hospital, Lund University, Malmö, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea> Department of Surgery, Skåne University Hospital, Lund University, Malmö</wicri:regionArea><wicri:noRegion>Malmö</wicri:noRegion></affiliation></author><author><name sortKey="Manjer, Jonas" sort="Manjer, Jonas" uniqKey="Manjer J" first="Jonas" last="Manjer">Jonas Manjer</name><affiliation wicri:level="1"><nlm:aff id="A34"> Department of Clinical Sciences Lund, Oncology and Pathology, Lund University, Lund, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea> Department of Clinical Sciences Lund, Oncology and Pathology, Lund University, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A35"> Department of Surgery, Skåne University Hospital, Lund University, Malmö, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea> Department of Surgery, Skåne University Hospital, Lund University, Malmö</wicri:regionArea><wicri:noRegion>Malmö</wicri:noRegion></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J." last="Wareham">Nicholas J. Wareham</name><affiliation wicri:level="4"><nlm:aff id="A36"> Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation wicri:level="1"><nlm:aff id="A37"> University of Cambridge School of Clinical Medicine, Clinical Gerontology, Cambridge, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> University of Cambridge School of Clinical Medicine, Clinical Gerontology, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Byrne, Karl Smith" sort="Byrne, Karl Smith" uniqKey="Byrne K" first="Karl Smith" last="Byrne">Karl Smith Byrne</name><affiliation wicri:level="4"><nlm:aff id="A38"> Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name><affiliation wicri:level="4"><nlm:aff id="A38"> Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Gunter, Marc J" sort="Gunter, Marc J" uniqKey="Gunter M" first="Marc J." last="Gunter">Marc J. Gunter</name><affiliation wicri:level="3"><nlm:aff id="A39"> Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Merritt, Melissa A" sort="Merritt, Melissa A" uniqKey="Merritt M" first="Melissa A." last="Merritt">Melissa A. Merritt</name><affiliation wicri:level="3"><nlm:aff id="A39"> Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name><affiliation wicri:level="3"><nlm:aff id="A39"> Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Cramer, Daniel W" sort="Cramer, Daniel W" uniqKey="Cramer D" first="Daniel W." last="Cramer">Daniel W. Cramer</name><affiliation wicri:level="2"><nlm:aff id="A1"> Ob/Gyn Epidemiology Center, Brigham and Women's Hospital, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Ob/Gyn Epidemiology Center, Brigham and Women's Hospital, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name><affiliation wicri:level="2"><nlm:aff id="A2"> Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></analytic><series><title level="j">Clinical cancer research : an official journal of the American Association for Cancer Research</title><idno type="ISSN">1078-0432</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose</title><p id="P1">About 60% of ovarian cancers are diagnosed at late stage, when 5-year survival is less than 30% in contrast to 90% for local disease. This has prompted search for early detection biomarkers. For initial testing, specimens taken months or years before ovarian cancer diagnosis are the best source of information to evaluate early detection biomarkers. Here we evaluate the most promising ovarian cancer screening biomarkers in prospectively collected samples from the European Prospective Investigation into Cancer and Nutrition study.</p></sec><sec id="S2"><title>Experimental Design</title><p id="P2">We measured CA125, HE4, CA72.4 and CA15.3 in 810 invasive epithelial ovarian cancer cases and 1,939 controls. We calculated the sensitivity at 95% and 98% specificity as well as Area under the Receiver Operator Curve (C-statistic) for each marker individually and in combination. Additionally, we evaluated marker performance by stage at diagnosis and time between blood draw and diagnosis.</p></sec><sec id="S3"><title>Results</title><p id="P3">We observed the best discrimination between cases and controls within six months of diagnosis for CA125 (C-statistic=0.92), then HE4 (0.84), CA72.4 (0.77), and CA15.3 (0.73). Marker performance declined with longer time between blood draw and diagnosis and for earlier staged disease. However, assessment of discriminatory ability at early stage was limited by small numbers. Combinations of markers performed modestly, but significantly better than any single marker.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">CA125 remains the single best marker for the early detection of invasive epithelial ovarian cancer, but can be slightly improved by combining with other markers. Identifying novel markers for ovarian cancer will require studies including larger numbers of early stage cases.</p></sec></div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Danemark</li><li>Espagne</li><li>Finlande</li><li>France</li><li>Grèce</li><li>Italie</li><li>Norvège</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>Bade-Wurtemberg</li><li>Catalogne</li><li>Communauté de Madrid</li><li>District de Karlsruhe</li><li>Grand Londres</li><li>Hovedstaden</li><li>Lombardie</li><li>Massachusetts</li><li>Oxfordshire</li><li>Piémont</li><li>Svealand</li><li>Utrecht (province)</li><li>Île-de-France</li><li>Østlandet</li></region><settlement><li>Barcelone</li><li>Cambridge</li><li>Copenhague</li><li>Heidelberg</li><li>Londres</li><li>Madrid</li><li>Milan</li><li>Orsay</li><li>Oslo</li><li>Oxford</li><li>Stockholm</li><li>Turin</li><li>Utrecht</li></settlement><orgName><li>Université Paris-Sud</li><li>Université d'Oxford</li><li>Université de Cambridge</li></orgName></list><tree><noCountry><name sortKey="Dossus, Laure" sort="Dossus, Laure" uniqKey="Dossus L" first="Laure" last="Dossus">Laure Dossus</name><name sortKey="Rinaldi, Sabina" sort="Rinaldi, Sabina" uniqKey="Rinaldi S" first="Sabina" last="Rinaldi">Sabina Rinaldi</name></noCountry><country name="États-Unis"><region name="Massachusetts"><name sortKey="Terry, Kathryn L" sort="Terry, Kathryn L" uniqKey="Terry K" first="Kathryn L." last="Terry">Kathryn L. Terry</name></region><name sortKey="Cramer, Daniel W" sort="Cramer, Daniel W" uniqKey="Cramer D" first="Daniel W." last="Cramer">Daniel W. Cramer</name><name sortKey="Fichorova, Raina N" sort="Fichorova, Raina N" uniqKey="Fichorova R" first="Raina N." last="Fichorova">Raina N. Fichorova</name><name sortKey="Fichorova, Raina N" sort="Fichorova, Raina N" uniqKey="Fichorova R" first="Raina N." last="Fichorova">Raina N. Fichorova</name><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name><name sortKey="Terry, Kathryn L" sort="Terry, Kathryn L" uniqKey="Terry K" first="Kathryn L." last="Terry">Kathryn L. Terry</name><name sortKey="Vitonis, Allison F" sort="Vitonis, Allison F" uniqKey="Vitonis A" first="Allison F." last="Vitonis">Allison F. Vitonis</name><name sortKey="Yamamoto, Hidemi S" sort="Yamamoto, Hidemi S" uniqKey="Yamamoto H" first="Hidemi S." last="Yamamoto">Hidemi S. Yamamoto</name><name sortKey="Yamamoto, Hidemi S" sort="Yamamoto, Hidemi S" uniqKey="Yamamoto H" first="Hidemi S." last="Yamamoto">Hidemi S. Yamamoto</name></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Schock, Helena" sort="Schock, Helena" uniqKey="Schock H" first="Helena" last="Schock">Helena Schock</name></region><name sortKey="Boeing, Heiner" sort="Boeing, Heiner" uniqKey="Boeing H" first="Heiner" last="Boeing">Heiner Boeing</name><name sortKey="Fortner, Renee T" sort="Fortner, Renee T" uniqKey="Fortner R" first="Renée T." last="Fortner">Renée T. Fortner</name><name sortKey="Husing, Anika" sort="Husing, Anika" uniqKey="Husing A" first="Anika" last="Hüsing">Anika Hüsing</name><name sortKey="Johnson, Theron" sort="Johnson, Theron" uniqKey="Johnson T" first="Theron" last="Johnson">Theron Johnson</name></country><country name="Danemark"><noRegion><name sortKey="Overvad, Kim" sort="Overvad, Kim" uniqKey="Overvad K" first="Kim" last="Overvad">Kim Overvad</name></noRegion><name sortKey="Tj Nneland, Anne" sort="Tj Nneland, Anne" uniqKey="Tj Nneland A" first="Anne" last="Tj Nneland">Anne Tj Nneland</name></country><country name="France"><region name="Île-de-France"><name sortKey="Boutron Ruault, Marie Christine" sort="Boutron Ruault, Marie Christine" uniqKey="Boutron Ruault M" first="Marie-Christine" last="Boutron-Ruault">Marie-Christine Boutron-Ruault</name></region><name sortKey="Boutron Ruault, Marie Christine" sort="Boutron Ruault, Marie Christine" uniqKey="Boutron Ruault M" first="Marie-Christine" last="Boutron-Ruault">Marie-Christine Boutron-Ruault</name><name sortKey="Mesrine, Sylvie" sort="Mesrine, Sylvie" uniqKey="Mesrine S" first="Sylvie" last="Mesrine">Sylvie Mesrine</name><name sortKey="Mesrine, Sylvie" sort="Mesrine, Sylvie" uniqKey="Mesrine S" first="Sylvie" last="Mesrine">Sylvie Mesrine</name><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name></country><country name="Italie"><region name="Piémont"><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name></region><name sortKey="Krogh, Vittorio" sort="Krogh, Vittorio" uniqKey="Krogh V" first="Vittorio" last="Krogh">Vittorio Krogh</name><name sortKey="Kuhn, Elisabetta" sort="Kuhn, Elisabetta" uniqKey="Kuhn E" first="Elisabetta" last="Kuhn">Elisabetta Kuhn</name><name sortKey="Panico, Salvatore" sort="Panico, Salvatore" uniqKey="Panico S" first="Salvatore" last="Panico">Salvatore Panico</name></country><country name="Australie"><noRegion><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name></noRegion></country><country name="Grèce"><noRegion><name sortKey="Benetou, Vassiliki" sort="Benetou, Vassiliki" uniqKey="Benetou V" first="Vassiliki" last="Benetou">Vassiliki Benetou</name></noRegion><name sortKey="Benetou, Vassiliki" sort="Benetou, Vassiliki" uniqKey="Benetou V" first="Vassiliki" last="Benetou">Vassiliki Benetou</name><name sortKey="Lagiou, Pagona" sort="Lagiou, Pagona" uniqKey="Lagiou P" first="Pagona" last="Lagiou">Pagona Lagiou</name><name sortKey="Lagiou, Pagona" sort="Lagiou, Pagona" uniqKey="Lagiou P" first="Pagona" last="Lagiou">Pagona Lagiou</name><name sortKey="Trichopoulou, Antonia" sort="Trichopoulou, Antonia" uniqKey="Trichopoulou A" first="Antonia" last="Trichopoulou">Antonia Trichopoulou</name><name sortKey="Trichopoulou, Antonia" sort="Trichopoulou, Antonia" uniqKey="Trichopoulou A" first="Antonia" last="Trichopoulou">Antonia Trichopoulou</name></country><country name="Pays-Bas"><noRegion><name sortKey="Bueno De Mesquita, H Bas" sort="Bueno De Mesquita, H Bas" uniqKey="Bueno De Mesquita H" first="H. Bas" last="Bueno-De-Mesquita">H. Bas Bueno-De-Mesquita</name></noRegion><name sortKey="Onland Moret, N Charlotte" sort="Onland Moret, N Charlotte" uniqKey="Onland Moret N" first="N. Charlotte" last="Onland-Moret">N. Charlotte Onland-Moret</name><name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H." last="Peeters">Petra H. Peeters</name></country><country name="Norvège"><noRegion><name sortKey="Gram, Inger Torhild" sort="Gram, Inger Torhild" uniqKey="Gram I" first="Inger Torhild" last="Gram">Inger Torhild Gram</name></noRegion><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name></country><country name="Suède"><region name="Svealand"><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name></region><name sortKey="Idahl, Annika" sort="Idahl, Annika" uniqKey="Idahl A" first="Annika" last="Idahl">Annika Idahl</name><name sortKey="Jirstrom, Karin" sort="Jirstrom, Karin" uniqKey="Jirstrom K" first="Karin" last="Jirström">Karin Jirström</name><name sortKey="Jirstrom, Karin" sort="Jirstrom, Karin" uniqKey="Jirstrom K" first="Karin" last="Jirström">Karin Jirström</name><name sortKey="Lundin, Eva" sort="Lundin, Eva" uniqKey="Lundin E" first="Eva" last="Lundin">Eva Lundin</name><name sortKey="Manjer, Jonas" sort="Manjer, Jonas" uniqKey="Manjer J" first="Jonas" last="Manjer">Jonas Manjer</name><name sortKey="Manjer, Jonas" sort="Manjer, Jonas" uniqKey="Manjer J" first="Jonas" last="Manjer">Jonas Manjer</name></country><country name="Finlande"><noRegion><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name></noRegion></country><country name="Espagne"><region name="Catalogne"><name sortKey="Duell, Eric J" sort="Duell, Eric J" uniqKey="Duell E" first="Eric J." last="Duell">Eric J. Duell</name></region><name sortKey="Ardanaz, Eva" sort="Ardanaz, Eva" uniqKey="Ardanaz E" first="Eva" last="Ardanaz">Eva Ardanaz</name><name sortKey="Ardanaz, Eva" sort="Ardanaz, Eva" uniqKey="Ardanaz E" first="Eva" last="Ardanaz">Eva Ardanaz</name><name sortKey="Ardanaz, Eva" sort="Ardanaz, Eva" uniqKey="Ardanaz E" first="Eva" last="Ardanaz">Eva Ardanaz</name><name sortKey="Etxezarreta, Nerea" sort="Etxezarreta, Nerea" uniqKey="Etxezarreta N" first="Nerea" last="Etxezarreta">Nerea Etxezarreta</name><name sortKey="Etxezarreta, Nerea" sort="Etxezarreta, Nerea" uniqKey="Etxezarreta N" first="Nerea" last="Etxezarreta">Nerea Etxezarreta</name><name sortKey="Navarro, Carmen" sort="Navarro, Carmen" uniqKey="Navarro C" first="Carmen" last="Navarro">Carmen Navarro</name><name sortKey="Navarro, Carmen" sort="Navarro, Carmen" uniqKey="Navarro C" first="Carmen" last="Navarro">Carmen Navarro</name><name sortKey="Navarro, Carmen" sort="Navarro, Carmen" uniqKey="Navarro C" first="Carmen" last="Navarro">Carmen Navarro</name><name sortKey="Sanchez, Maria Jose" sort="Sanchez, Maria Jose" uniqKey="Sanchez M" first="Maria-Jose" last="Sanchez">Maria-Jose Sanchez</name><name sortKey="Sanchez, Maria Jose" sort="Sanchez, Maria Jose" uniqKey="Sanchez M" first="Maria-Jose" last="Sanchez">Maria-Jose Sanchez</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J." last="Wareham">Nicholas J. Wareham</name></region><name sortKey="Byrne, Karl Smith" sort="Byrne, Karl Smith" uniqKey="Byrne K" first="Karl Smith" last="Byrne">Karl Smith Byrne</name><name sortKey="Gunter, Marc J" sort="Gunter, Marc J" uniqKey="Gunter M" first="Marc J." last="Gunter">Marc J. Gunter</name><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><name sortKey="Merritt, Melissa A" sort="Merritt, Melissa A" uniqKey="Merritt M" first="Melissa A." last="Merritt">Melissa A. Merritt</name><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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